Y chromosome sequences in Turner's syndrome and risk of gonadoblastoma or virilisation.
نویسنده
چکیده
منابع مشابه
Frequent Detection of Y Chromosome Sequences in Japanese Turner's Syndrome by Southern Blot Analysis of Amplified DNA
In Turner's syndrome, the detection of Y chromosome sequences is very important because the presence of the Y chromosome increases the risk of gonadoblastoma induction. Some recent studies have indicated the presence of the Y chromosome in patients with Turner's syndrome, by methods in which the Y chromosome was not detected by a standard cytogenetic method, but these studies concentrated on a ...
متن کاملDetection of Y chromosomal material in patients with a 45,X karyotype by PCR method.
A 45,X karyotype is one of the common chromosomal abnormalities characterized by short stature, lack of development of secondary sexual characteristics, webbed neck and cubitus valgus. This phenotype was described by Turner in 1938 and was called Turner syndrome (TS). About 40-60% of the patients with TS phenotype have a 45,X karyotype, the rest either have a structurally abnormal X or Y chromo...
متن کاملHidden Y Chromosome Mosaicism in 48 Egyptian Patients with Turner's Syndrome
Background. The presence of Y chromosome material in Turner's syndrome (TS) patients is a risk factor for the development of gonadoblastoma. Although conventional cytogenetic analysis is the definitive diagnosis of TS, low level Y chromosome mosaicism may be missed. Molecular analysis has demonstrated a higher proportion of mosaicism, but there is controversy regarding the prevalence of Y chrom...
متن کاملY chromosome in Turner syndrome: review of the literature.
Turner syndrome (TS) is one of the most common types of aneuploidy among humans, and is present in 1:2000 newborns with female phenotype. Cytogenetically, the syndrome is characterized by sex chromosome monosomy (45,X), which is present in 50-60% of the cases. The other cases present mosaicism, with a 45,X cell line accompanied by one or more other cell lines with a complete or structurally abn...
متن کامل[Prevalence of Y-chromosome sequences and gonadoblastoma in Turner syndrome].
OBJECTIVE To assess the prevalence of Y-chromosome sequences and gonadoblastoma in patients with Turner syndrome using molecular techniques. DATA SOURCE A literature search was performed in Pubmed, limiting the period of time to the years 2005 to 2014 and using the descriptors: Turner syndrome and Y sequences (n=26), and Turner syndrome and Y-chromosome material (n=27). The inclusion criteria...
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عنوان ژورنال:
- Lancet
دوره 343 8891 شماره
صفحات -
تاریخ انتشار 1994